NEW
 AET 2024│Deeper Therapeutic Antibody Developmental Insights via Comprehensive Fc Effector Function ProfilingÂ
Shashi Jatiani, PhD.
Comprehensive Profiling of Approved Anti-CD20 mAbs Using Fc Effector Function Platform
P. Hsueh, M. Friedman, S. Jatiani (2024)Â
Publications
Systems serology for evaluation of HIV vaccine trials
Ackerman ME, et al. Immunol Rev. 2017 Jan; 275(1): 262–270.
High-resolution definition of humoral immune response correlates of effective immunity against HIV
Alter G, Dowell KG, et al. Mol Syst Biol. 2018 Mar; 14(3): e7881.Â
Systems serology: profiling vaccine induced humoral immunity against HIV
Chung AW, et al. Retrovirology. 2017; 14: 57.
Innate transcriptional effects by adjuvants on the magnitude, quality, and durability of HIV envelope responses in NHPs
Francica JR, et al. Blood Adv. 2017 Nov 28; 1(25): 2329–2342.
Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys
Barouch DH, et al. Science. Author manuscript; available in PMC 2016 Jan 17.
Beyond binding: antibody effector functions in infectious diseases
Lu LL, et al. Nat Rev Immunol. 2018 Jan; 18(1): 46–61.
Polyfunctional Fc-effector profiles mediated by IgG subclass selection distinguish RV144 and VAX003 vaccines
Chung AW, et al. Science Translational Medicine 19 Mar 2014: Vol. 6, Issue 228, pp. 228ra38
Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology
Chung AW, et al. Cell. 2015 Nov 5; 163(4): 988–998.
A Functional Role for Antibodies in Tuberculosis
Lu LL, et al. Cell. 2016 Oct 6; 167(2): 433–443.e14.
A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus
Bronwyn M. Gunn, et al. Cell Host Microbe. 2018 Aug 8; 24(2): 221–233.e5.
Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection
Erica Ollmann Saphire*, et al. Cell. 2018 Aug 9; 174(4): 938–952.e13.
Evaluation of a mosaic HIV 1 vaccine in a multicentre randomised double blind placebo controlled phase 1 2a clinical trial APPROACH and in rhesus monkeys.
Barouch DH, et al. Lancet. 2018 Jul 21; 392(10143): 232–243.
Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination.Â
Suscovich TJ, et. al. Science Translational Medicine. 2020 Jul; 12(553): eabb4757
Distinct Early Serological Signatures Track with SARS-CoV-2 Survival
Atyeo et al. Immunity (2020)
View from the Fc: Five Rules for mAb Development Risk Reduction
SeromYx Team (2024)
Comprehensive Profiling of Approved Anti-CD20 mAbs Using Fc Effector Function Platform
P. Hsueh, M. Friedman, S. Jatiani (2024)Â
Posters & Presentations
Antibody Engineering & Therapeutics US 2024
Deeper Therapeutic Antibody Developmental Insights via Comprehensive Fc Effector Function ProfilingÂ
Shashi Jatiani, PhD.
Festival of Biologics Europe 2024 Poster
Comprehensive Immune Profiling of Approved Anti-CD20 mAbs Using SeromYx’s Fc Effector Function Platform
Shashi Jatiani, PhD.
Antibody Engeering & Therapeutics Europe 2024
Comprehensive High Throughput Fc Effector Function Profiling as a Strategy for Improved Efficacy and Safety of Antibody Therapeutics
Shashi Jatiani, PhD.
Fc-Mediated Function Summit 2024
Broad Fc effector function profiling
for safer and more effective
antibody therapeutics
Lenny Moise, PhD.
