Immune insight for better products
Publications Scientific articles about Systems Serology Ackerman ME, et al., Systems serology for evaluation of HIV vaccine trials. Immunol Rev. 2017 Jan; 275(1): 262–270. Alter G, Dowell KG, et al., High-resolution definition of humoral immune response correlates of effective immunity against HIV. Mol Syst Biol. 2018 Mar; 14(3): e7881. Chung AW, et al., Systems serology: profiling vaccine induced humoral immunity against HIV. Retrovirology. 2017; 14: 57. Francica JR, et al., Innate transcriptional effects by adjuvants on the magnitude, quality, and durability of HIV envelope responses in NHPs. Blood Adv. 2017 Nov 28; 1(25): 2329–2342. Barouch DH, et al., Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys. Science. Author manuscript; available in PMC 2016 Jan 17. Lu LL, et al., Beyond binding: antibody effector functions in infectious diseases. Nat Rev Immunol. 2018 Jan; 18(1): 46–61. Chung AW, et al., Polyfunctional Fc-effector profiles mediated by IgG subclass selection distinguish RV144 and VAX003 vaccines. Science Translational Medicine 19 Mar 2014: Vol. 6, Issue 228, pp. 228ra38 Chung AW, et al., Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology. Cell. 2015 Nov 5; 163(4): 988–998. Lu LL, et al., A Functional Role for Antibodies in Tuberculosis. Cell. 2016 Oct 6; 167(2): 433–443.e14. Bronwyn M. Gunn, et al., A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus. Cell Host Microbe. 2018 Aug 8; 24(2): 221–233.e5. Erica Ollmann Saphire*, et al., Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection. Cell. 2018 Aug 9; 174(4): 938–952.e13. Barouch DH, et al., Evaluation of a mosaic HIV 1 vaccine in a multicentre randomised double blind placebo controlled phase 1 2a clinical trial APPROACH and in rhesus monkeys. Lancet. 2018 Jul 21; 392(10143): 232–243.